Yazar "Tokay, Esra" için listeleme
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Amplification of GC-rich ADAMTS-2 and URG4/URGCP promoter regions with optimized combination of PCR enhancers
Alper, Meltem; Tokay, Esra; Koçkar, Feray (Tubitak Scientific & Technical Research Council Turkey, 2016)PCR is an effective and widely used method for the amplification of target DNA fragments in vitro. The templates that have high guanine-cytosine (GC) content, complex secondary structures, or short tandem repeats are ... -
Characterisation of the human URG-4 (Up-Regulated Gene 4) gene promoter
Köçkar, Feray; Tokay, Esra (Wiley-Blackwell, 2014) -
Epidermal growth factor mediates up-regulation of URGCP oncogene in human hepatoma cancer cells
Tokay, Esra (Pleiades Publishing Inc, 2021)Hepatocellular Carcinoma (HCC) is the fourth leading cause of cancer-related death in the World. Epidermal Growth Factor Receptor (EGFR) pathway plays an important role in HCC tumorigenesis. In the tumor microenvironment ... -
Expression analysis of URG4 (upregulated gene 4) in osteoblast-like cells, Saos-2 and MG63
Köçkar, Feray; Tokay, Esra; Alper, Meltem (Wiley-Blackwell, 2011)URG4 is a novel gene firstly found in uninfected liver cells stimu-lated by HBxAg (Hepatitis B virus encoded X antigen) and HCC(Hepatocellular Carcinoma) cells. It is associated with cellgrowth, growth factor-independent ... -
Identification of intracellular pathways through which TGF-beta 1 upregulates URG-4/URGCP gene expression in hepatoma cells
Tokay, Esra; Köçkar, Feray (Pergamon-Elsevier Science Ltd,, 2016)Aims: Up-regulated gene 4 (URG-4/URGCP) was strongly expressed in Hepatitis B infected liver and correlated with HBxAG (Hepatitis B x Antigen) protein and found to promote hepatocellular cancer. Transforming growth factor ... -
In silico and expression analysis of urg-4/urgcp gene in different cancer cells
Tokay, Esra; Köçkar, Feray (Nobel Science and Research Center, 2015)Upregulated gene 4 (URG-4/URGCP) located in chromosome 7 (7p13), was originally suggested as one of the HBxAg upregulated genes in hepatoma cells and implicated in tumorogenesis process in different cells. In this study ... -
In silico and in vitro determination of potential RSK inhibitors for colon cancer therapy
Mülhim, Ufuk; Tokay, Esra; Köçkar, Feray; Kalın, Sevil; Önder, F. Cömert (Wiley, 2024)The Ribosomal S6 kinase (RSK) family comprises four isoforms (RSK1/2/3/4), functioning as serine/threonine kinases. RSK plays a crucial role in various physiological processes like cell growth, proliferation, and migration. ... -
In-vitro apoptotic and metastatic effect of ibuprofen on hepatocellular carcinoma cells
Tokay, Esra; Köçkar, Feray (Wiley, 2024)Ibuprofen (2RS)1 [4(2methylpropyl)phenyl] propionic acid is the first derivative of propionic acid developed in 1969 as an alternative to aspirin. In the literature, it has been determined that ibuprofen has a favorable ... -
In-vitro SMA model; SMN1 gene knockdown in SH-SY5Y cells
Tokay, Esra; Çapraz, Hasan; Köçkar, Feray (Wiley, 2024)Spinal muscular atrophy is an autosomalrecessive disorder characterized by degeneration of motor neurons in the spinal cord and caused by mutations in the survival motor neuron 1 gene, SMN1. The phenotype is extremely ... -
Investigation of the effects of post-operative intraperitoneal, oral, and rectal phenytoin administration on colorectal anastomosis in rats
Duran, Ali; Çay, Ferhat; Hacıoğlu, Nelin; Tokay, Esra; Köçkar, Feray; Altun, Eren; Başbuğ, Murat; Şahin, Azad Gazi (Turkish Assoc Trauma Emergency Surgery, 2022)BACKGROUND: Anastomotic leakage is the most feared complication after colonic anastomosis. The purpose of the study is to determine the effects of phenytoin applied by different application routes, on the healing process ... -
Is phenytoin a safe agent for staple line recovery after gastric sleeve surgery in rats?
Çay, Ferhat; Duran, Ali; Tokay, Esra; Hacıoğlu, Nelin; Köçkar, Feray; Altun, Eren; Kanat, Burhan Hakan (Turkish Association of Trauma and Emergency Surgery, 2023)BACKGROUND: The most challenging and mortal complication of gastric sleeve surgery (SG) is staple line leakage. Although many agents have been used for increasing tissue healing on the stapler line, there is still no ... -
Is thymoquinone promising anticancer agent in hepatoma cell line?
Karaman, Musa; Köçkar, İpek Ece; Tokay, Esra; Köçkar, Feray (Wiley-Blackwell, 2016)The biological activity ofNigella sativaseeds is mainly attributedto its essential oil component which is pre-dominantly (30–48%)thymoquinone (TQ). Therapeutic effect of TQ was exhibited inmany diseases including inflammation, ... -
İnsan URG-4 (Up-Regulated Gene 4) geninin transkripsiyonel regülasyonu
Tokay, Esra (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2014)Up-regulated gene 4 (URG-4) geni, ilk olarak HBxAG proteinin doğal regülatörü olarak bulunmuştur. Sitokinlerle regülasyonu ve transkripsiyonel aktivitesi ile ilgili literatürde herhangi bir çalışma bulunmamaktadır. URG-4 ... -
Kolon karsinoma doku ve hücrelerinde URG-4/URGCP geninin proliferatif ve metastatik genlerle ilişkisi
Abdusalamova, Tunzala (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2022)URG-4/URGCP'nin, kolon kanseri hücreleri ve dokularında yapılmış herhangi bir çalışma mevcut değildir. Bu amaçla çalışmalarımızda 15 adet taze kolon kanserli ve normal kolon dokularından RNA izolasyonu gerçekleştirilmiştir. ... -
Prodrugs for nitroreductase based cancer therapy-1: metabolite profile, cell cytotoxicity and molecular modeling ınteractions of nitro benzamides with ssap-ntrb
Güngör, Tuğba; Yetiş, Gülden; Önder, Ferah Cömert; Tokay, Esra; Tok, Tugba Taşkın; Çelik, Ayhan; Ay, Mehmet; Köçkar, Feray (Bentham Science Publ Ltd, 2018)Background: Directed Enzyme Prodrug Therapy (DEPT) as an alternative method against conventional cancer treatments, in which the non-toxic prodrug is converted to highly cytotoxic derivative, has attracted an ample attentions ... -
Prodrugs for nitroreductase based cancer therapy-2: Novel amide/Ntr combinations targeting PC3 cancer cells
Güngör, Tuğba; Önder, Ferah Cömert; Tokay, Esra; Gülhan, Ünzile Güven; Hacıoğlu, Nelin; Tok, Tuğba Taşkın; Çelik, Ayhan; Köçkar, Feray; Ay, Mehmet (Elsevier France-Editions Scientifiques Medicales Elsevier, 2019)The use of nitroreductases (NTR) that catalyze the reduction of nitro compounds by using NAD(P)H in GDEPT (Gene-directed enzyme prodrug therapy) studies which minimize toxicity at healthy cells and increases concentration ... -
Prodrugs for nitroreductase based cancer therapy-4: Towards prostate cancer targeting: Synthesis of N-heterocyclic nitro prodrugs, Ssap-NtrB enzymatic activation and anticancer evaluation
Güngör, Tuğba; Tokay, Esra; Gülhan, Ünzile Güven; Hacıoğlu, Nelin; Çelik, Ayhan; Köçkar, Feray; Ay, Mehmet (Academic Press Inc Elsevier Science, 2020)In this study, various N-heterocyclic nitro prodrugs (NHN1-16) containing pyrimidine, triazine and piperazine rings were designed and synthesized. The final compounds were identified using FT-IR, H-1 NMR, C-13 NMR as well ... -
Prodrugs for nitroreductase based cancer therapy-5: Development of trinitroaniline Prodrugs/Ssap-NtrB combinations for liver cancer using intracellular and extracellular conditions
Hacıoğlu, Nelin; Güngör, Tuğba; Tokay, Esra; Gülhan, Ünzile Güven; Çelik, Ayhan; Ay, Mehmet; Köçkar, Feray (Wiley-V C H Verlag GMBH, 2021)In this study, a series of trinitroaniline derivatives (TNA1-8) were synthesized and investigated as potential antitumor agents for enzyme-prodrug therapy. Enzymatic efficiency of Ssap-NtrB on prodrug candidates was ... -
Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer
Tokay, Esra; Güngör, Tuğba; Hacıoğlu, Nelin; Önder, Ferah Cömert; Gülhan, Ünzile Güven; Tok, Tuğba Taşkın; Çelik, Ayhan; Ay, Mehmet; Köçkar, Feray (Elsevier France-Editions Scientifiques Medicales Elsevier, 2020)Prodrugs for targeted tumor therapies have been extensively studied in recent years due to not only maximising therapeutic effects on tumor cells but also reducing or eliminating serious side effects on healthy cells. This ... -
A simple way to synthesize tartaric acid, ascorbic acid and their mixture coated superparamagnetic iron oxide nanoparticles with high saturation magnetisation and high stability against oxidation: Characterizations and their biocompatibility studies
Özel, Fatmahan; Karaağaç, Öznur; Tokay, Esra; Köçkar, Feray; Köçkar, Hakan (Elsevier Science BV, 2019)A simple way to synthesise biocompatible superparamagnetic iron oxide nanoparticles coated with ascorbic acid, tartaric acid and a mixture of ascorbic acid and tartaric acid is proposed. The iron oxide nanoparticles were ...
