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Prodrugs for nitroreductase based cancer therapy-1: metabolite profile, cell cytotoxicity and molecular modeling ınteractions of nitro benzamides with ssap-ntrb

Güngör, Tuğba; Yetiş, Gülden; Önder, Ferah Cömert; Tokay, Esra; Tok, Tugba Taşkın; Çelik, Ayhan; Ay, Mehmet; Köçkar, Feray (Bentham Science Publ Ltd, 2018)

Background: Directed Enzyme Prodrug Therapy (DEPT) as an alternative method against conventional cancer treatments, in which the non-toxic prodrug is converted to highly cytotoxic derivative, has attracted an ample attentions ...