Yazar "Sinan, Selma" için listeleme
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Amphenicol and macrolide derived antibiotics inhibit paraoxonase enzyme activity in human serum and human hepatoma cells (HepG2) in vitro
Sinan, Selma; Köçkar,Feray; Gençer, Nahit; Yıldırım, Hatice Kalkan; Arslan, Oktay (Maik Nauka/Interperiodıca/Springer, 2006)Human serum paraoxonase (hPON 1) was separately purified by ammonium sulfate precipitation and hydrophobic interaction chromatography The in vitro effects of commonly used antibiotics, namely clarithromycin and chloramphenicol, ... -
Antidepressant and antipsychotic drugs differentially affect pon1 enzyme activity
Avcıkurt, Ayla Solmaz; Sinan, Selma; Köçkar, Feray (Taylor & Francis Ltd, 2015)Human serum paraoxonase (PON1, EC 3.1.8.1.) is a high-density lipid (HDL)-associated, calcium-dependent enzyme. In this study, the effects of Haloperidol, Fluoxetine hydrochloride, Diazepam and Acepromazine drugs used for ... -
Antioxidant properties of various olive cultivars
Gençer, Nahit; Sinan, Selma; Arslan, Oktay (2009)Virgin olive oil is a typical component of the Mediterranean diet, consumed unrefined and rich in important molecules, such as minor polar compounds (tyrosol, ferulic acid and caffeic acid). These molecules not only influence ... -
The azoarcus group i intron ribozyme misfolds and is accelerated for refolding by atp-dependent rna chaperone proteins
Sinan, Selma; Yuan, Xiaoyan; Russell, Rick (Amer Soc Biochemistry Molecular Biology Inc, 2011)Structured RNAs traverse complex energy landscapes that include valleys representing misfolded intermediates. In Neurospora crassa and Saccharomyces cerevisiae, efficient splicing of mitochondrial group I and II introns ... -
Bazı ilaçların paraoksonaz izoenzimleri (PON1 ve PON2) üzerine etkilerinin belirlenmesi
Avcıkurt, Ayla Solmaz (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2009)Bu çalışmanın amacı, bazı ilaçların, fizyolojik ve pato-fizyolojik durumlarda önemleri belirlenmiş PON1 ve PON2 enzimleri üzerinde in vitro etkilerinin belirlenmesidir. Çalışma, günümüzde kullanımı artan antidepresan ve ... -
Characterization of polyphenoloxidase from wild pear (Pyrus elaegrifolia)
Yerlitürk, Fatma Ülker; Arslan, Oktay; Sinan, Selma; Gençer, Nahit; Güler, Özen Özensoy (Wiley, 2008)Wild pear polyphenoloxidase (PePPO) was extracted and purified using a Sepharose 4B-L-tyrosine-p-amino benzoic acid affinity column. Optimum conditions for pH, temperature and heat inactivation were determined. At the ... -
Comparison of hydratase, esterase activities and inhibition manner of mutant Asn67/Ile and Leu204/Ser of human CAII
Türkoğlu, Sumeyye Aydoğan; Köçkar, Feray; Aydın, Meltem; Sinan, Selma; Arslan, Oktay (Blackwell Publishing, 2008)Carbonic anhydrases (CAs; also known as carbonate dehydratases EC 4.2.1.1) are a family of enzymes which catalyze the reversible reaction from H2O and CO2 to HCO3 - ions. Carbonic anhydrases are ubiquitous metalloenzymes ... -
The determination of effect of some antibiotics on paraoxonase 2 (PON2) enzyme activities in human macrophages cell
Avcıkurt, Ayla Solmaz; Köçkar, Feray; Sinan, Selma (Wiley-Blackwell, 2015)The human paraoxonase (hPON) gene family includes threemembers: PON1, PON2, and PON3, located adjacent to eachother on the long arm of chromosome 7. The three hPONs shareapproximately 65% identity at the amino acid level ... -
Determination of venom components from the endoparasitoid wasp Pimpla turionellae L. (Hymenoptera : Ichneumonidae)
Uçkan, Fevzi; Sinan, Selma; Savaşçı, Şahin; Ergin, Ekrem (Entomol Soc Amer, 2004)Venom from the endoparasitoid wasp Pimpla turionellae L. (Hymenoptera; Ichneumonidae) was isolated in pure form. Total protein determination indicated an average value of 0.04 mug protein per venom sac. The molecular weights ... -
Differential effects of some antibiotics on paraoxonase enzyme activity on human hepatoma cells (hepg2) in vitro
Köçkar, Feray; Sinan, Selma; Yıldırım, Hatice; Arslan, Oktay (Taylor & Francis Ltd, 2010)Serum paraoxonase (aryldialkylphosphatase, EC 3.1.8.1., PON1) is an esterase protein synthesised by the liver and released into the serum, where it is associated with HDL lipoproteins. In this study, we have determined the ... -
Effects of some antibiotics on enzyme activities of carbonic anhydrase from erythrocytes in vivo and in vitro
In this study, firstly, the effects of eight antibiotics namely, chlarithromycin, chloramphenicol, rifamycin SV, clindamycin phosphate, ciprofloxacin, gentamycin sulfate, sodium ampicillin and cefazolin sodium, on human ... -
Effects of some antibiotics on paraoxonase from human serum in vitro and from mouse serum and liver in vivo
Sinan, Selma; Köçkar, Feray; Gençer, Nahit; Yıldırım, Hatice; Arslan, Oktay (Pharmaceutical Soc Japan, 2006)Paraoxonase (PON1, EC 3.1.8.1) is an esterase protein which plays multifunctional role in metabolism. Therefore, in this study the effects of commonly used antibiotics, namely sodium ampicillin, ciprofloxacin, rifamycin ... -
Immobilization of beta-glucosidase purified from mandarin (Citrus reticulata) fruit to superparamagnetic nanoparticles and its aroma quality enhancing effect
Acar, Mesut; Turan, Yusuf; Sinan, Olcay; Sinan, Selma (SciCell s.r.o., 2023)This paper reports on novel and efficient enhancement effects of fruit juice aroma using immobilized β-glucosidase, the enzyme involved in important functions in living organisms, onto superparamagnetic nanoparticles Fe3O4 ... -
In vitro inhibition effect of some dihydroxy coumarin compounds on purified human serum paraoxonase 1 (pon1)
Erzengin, Mahmut; Başaran, İsmet; Çakır, Ümit; Aybey, Aynur; Sinan, Selma (Humana Press Inc, 2012)Human serum paraoxonase 1 (PON1; EC 3.1.8.1) is a high-density lipoprotein associated, calcium-dependent enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect the low-density lipoprotein ... -
In vitro inhibition effects of some coumarin derivatives on human erythrocytes glucose-6-phosphate dehydrogenase activities
Hopa, Ersin; Başaran, İsmet; Sinan, Selma; Turan, Yusuf; Çakır, Ümit (Taylor & Francıs Ltd, 2014)Inhibitory effects of some synthesized dihydroxycoumarin compounds on purified G6PD were investigated. For this purpose, initially human erythrocyte G6PD was purified 7069-fold in a yield of 33.6% by using ammonium sulfate ... -
In vitro inhibition effects of some new sulfonamide inhibitors on human carbonic anhydrase I and II
Çakır, Ümit; Uğraş, Halil İbrahim; Özensoy, Özen; Sinan, Selma; Arslan, Oktay (Taylor & Francis Ltd, 2004)A new series of aromatic and heterocyclic sulfonamides, including six new derivatives, 2-(3-cyclohexene-1-carbamido)-1,3,4-thiadiazole-5-sulfonamide (CCTS), 4-(3-cyclohexene-1-carbamido) methyl-benzenesulfonamide (CCBS), ... -
In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds
Başaran, İsmet; Sinan, Selma; Çakır, Ümit; Bulut, Mustafa; Arslan, Oktay; Özensoy, Özen (Taylor & Francis Ltd, 2008)A new series of 6, 7-dihydroxy-3-(methylphenyl) chromenones, including three new derivatives, i.e. 6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one (OPC); 6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one (MPC); ... -
In vitro inhibition of the carbonic anhydrase from saanen goat (Capra hircus) with pesticides
Sinan, Selma; Gençer, Nahit; Turan, Yusuf; Arslan, Oktay (Academic Press Inc Elsevier Science, 2007)This study was conducted to determine the in vitro effects of four commonly used pesticides (Nuarimol(Tm), Fenarimol(TM), Parathionmethyl(Tm) and 2,4-D-TM) on erythrocyte carbonic anhydrase (CA) activity from Saanen goats ... -
In vitro inhibition of the paraoxonase from human serum with sulfonamide
Sinan, Selma (Academic Journals, 2008)This study was conducted to determine the in vitro effects of sulfonamide on human serum paraoxonase (PON1) activity. The enzyme was purified by two-step using ammonium sulfate precipitation and sepharose-4B-L-tyrosine-1 ... -
In vivo effects of curcumin on the paraoxonase, carbonic anhydrase, glucose-6-phosphate dehydrogenase and beta-glucosidase enzyme activities in dextran sulphate sodium-induced ulcerative colitis mice
Yıldırım, Hatice; Sunay, Fatma Bahar; Sinan, Selma; Köçkar, Feray (Taylor & Francis Ltd, 2016)Increases in the risk of infections and malignancy due to immune suppressive therapies of inflammatory bowel diseases (IBDs) have led the researchers to focus on more nontoxic and acceptable natural products like curcumin. ...
