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The effects of bronchodilator drugs and antibiotics used for respiratory infection on human erythrocyte carbonic anhydrase I and II isozymes
Sarıoğlu, Nurhan; Bilen, Çiğdem; Saçkes, Zübeyde; Gencer, Nahit (Taylor & Francis Ltd, 2015)Carbonic anhydrase (CA) is an enzyme which plays role/roles in various homeostatic mechanisms, such as the acid-base balance and electrolyte secretion in various tissues. This study aimed to determine and to compare possible ... -
An examination of hyaluronidase enzyme activity in four different sheep breeds
Arslan, Mikail; Saçkes, Zübeyde; Kaya, Mustafa Oğuzhan (Wiley-Blackwell, 2016)Hyaluronidases are excessively found in nature and involved innumerous biological functions. Hyaluronidases primarily degradehyaluronic acid (HA) and have significant role in fertilizationduring acrosomal reactions. ... -
Synthesis and biological evaluation of new 4-thiazolidinone derivatives as carbonic anhydrase inhibitors
Genç, Hayriye; Çeken, Büşra; Bilen, Çiğdem; Saçkes, Zübeyde; Gencer, Nahit; Arslan, Oktay (Bentham Science Publ Ltd, 2017)Background: The catalytically active site of CA enzyme is Zn (II) bound hydroxide ion part which acts as a strong nucleophile (at neutral pH) on the CO2 molecule bound in a hydrophobic pocket nearby. We designed a series ... -
Synthesis and evaluation of new phthalazine substituted beta-lactam derivatives as carbonic anhydrase inhibitors
Berber, Nurcan; Arslan, Mustafa; Bilen, Çiğdem; Saçkes, Zübeyde; Gencer, Nahit; Arslan, Oktay (Maik Nauka / Interperiodica / Springer, 2015)A new series of phthalazine substituted beta-lactam derivatives were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA I and II) were evaluated. 2H-Indazolo[2,1-b]phthalazine-trione ... -
Yeni tadalafil türevlerinin bazı izoenzimler üzerine etkilerinin araştırılması
Saçkes, Zübeyde (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2018)Araştırmamızın birinci bölümünde, tadalafil ve yeni sentezlenen tadalafil türevlerinin siklik nükleotid fosfodiesteraz 1 (PDE1) izoenzimi üzerine inhibisyon etkileri saptanmıştır. Tadalafil (IC50=178 µM), alliltadalafil ...
