Yazar "Sönmez, Fatih" için listeleme
-
The effect of total anthocyanins extracted from sweet cherry cultivars on carbonic anhydrases and antioxidant activity
Sönmez, Fatih; Güneşli, Zuhal; Demir, Taki; Çıkrıkcı, Kübra; Ergün, Adem; Gencer, Nahit; Arslan, Oktay (Springer, 2022)Total anthocyanins were extracted from eleven sweet cherry cultivars grown in Sakarya, Turkey. In vitro inhibition effects of extracted total anthocyanins on purified carbonic anhydrase I and II were investigated by using ... -
Evaluation of carbonic anhydrase and paraoxonase inhibition activities and molecular docking studies of highly water-soluble sulfonated phthalocyanines
Güzel, Emre; Sönmez, Fatih; Erkan, Sultan; Çıkrıkçı, Kübra; Ergun, Adem; Gencer, Nahit; Arslan, Oktay; Koçak, Makbule Burkut (Scientific Technical Research Council Turkey-Tubitak, 2020)The investigation of carbonic anhydrase and paraoxonase enzyme inhibition properties of water-soluble zinc and gallium phthalocyanine complexes (1 and 2) are reported for the first time. The binding of p-sulfonylphenoxy ... -
Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors
Sönmez, Fatih; Sevmezler, Sedat; Atahan, Alparslan; Ceylan, Mustafa; Demir, Dudu; Gençer, Nahit; Arslan, Oktay; Küçükislamoğlu, Mustafa (Pergamon-Elsevier Science Ltd, 2011)A newly series of 4-(phenylurenyl) chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. ... -
Extraction and biological activity of total anthocyanins from sweet cherry cultivars as polyphenol oxidase inhibitors
Demir, Taki; Sönmez, Fatih; Bilen, Çiğdem; Gençer, Nahit (WFL Publisher Ltd., 2013)Total anthocyanins were extracted from six sweet cherry cultivars grown in Sakarya, Turkey, and their inhibitory effects on the diphenolase activity of banana polyphenol oxidase (PPO) were evaluated. The PPO was purified ... -
In vitro inhibition effect and structure-activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase I and II
Sönmez, Fatih; Bilen, Çiğdem; Sümersan, Sinem; Gençer, Nahit; Işık, Semra; Arslan, Oktay; Küçükislamoğlu, Mustafa (Taylor & Francis Ltd, 2014)In this study, in vitro inhibitory effects of some saccharin derivatives on purified carbonic anhydrase I and II were investigated using CO2 as a substrate. The results showed that all compounds inhibited the hCA I and hCA ... -
In vitro inhibition effects on erythrocyte carbonic anhydrase I and II and structure-activity relationships of cumarylthiazole derivatives
Kurt, Belma Zengin; Sönmez, Fatih; Gökçe, Başak; Ergün, Adem; Gencer, Nahit; Demir, Taki; Arslan, Oktay; Küçükislamoğlu, Mustafa (Maik Nauka, 2016)Coumarin and heterocyclic compounds incorporating urea have clinical applications as antiepileptics, diuretics, and antiglaucoma agents due to their carbonic anhydrase inhibitory properties. We investigated inhibition of ... -
Inhibition of carbonic anhydrase I and II with total anthocyanins extracted from sweet cherry cultivars
Demir, Taki; Güneşli, Zuhal; Sönmez, Fatih; Bilen, Çiğdem; Yavuz, Emre; Gencer, Nahit (GH Asachi Technical Univ IASI, 2015)Total anthocyanins were extracted from six sweet cherry cultivars grown in Sakarya, Turkey. In vitro inhibition effects of the extracted total anthocyanins on purified carbonic anhydrase I and II were investigated using ... -
New saccharin derivatives as tyrosinase inhibitors
Gençer, Nahit; Demir, Dudu; Sönmez, Fatih; Küçükislamoğlu, Mustafa (Pergamon-Elsevier Science Ltd, 2012)A newly series of 6-(phenylurenyl/thiourenyl) saccharin (6a-y) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. A 70-fold purification of the enzyme ... -
Synthesis and in vitro inhibition effect of new pyrido[2,3-d] pyrimidine derivatives on erythrocyte carbonic anhydrase i and ii
Kuday, Hilal; Sönmez, Fatih; Bilen, Çiğdem; Yavuz, Emre; Gençer, Nahit; Küçükislamoğlu, Mustafa (Hindawi Publishing Corporation, 2014)In vitro inhibition effects of indolylchalcones and new pyrido[2,3-d] pyrimidine derivatives on purified human carbonic anhydrase I and II (hCA I and II) were investigated by using CO2 as a substrate. The results showed ... -
Synthesis, antioxidant and carbonic anhydrase I and II inhibitory activities of novel sulphonamide-substituted coumarylthiazole derivatives
Kurt, Belma Zengin; Sönmez, Fatih; Bilen, Çiğdem; Ergün, Adem; Gençer, Nahit; Arslan, Oktay; Küçükislamoğlu, Mustafa (Taylor & Francis Ltd, 2016)New secondary benzenesulphonamide-substituted coumarylthiazole derivatives were synthesized and their inhibitory effects on purified carbonic anhydrase I and II were evaluated using CO2 as a substrate. The result showed ... -
Synthesis, biological activity and structure-activity relationship of novel diphenylurea derivatives containing tetrahydroquinoline as carbonic anhydrase I and II inhibitors
Atahan, Alparslan; Gencer, Nahit; Bilen, Çiğdem; Yavuz, Emre; Genç, Hayriye; Sönmez, Fatih; Zengin, Mustafa; Ceylan, Mustafa (Wiley-V C H Verlag GMBH, 2018)A series of novel tetrahydroquinoline derivatives containing urea moiety was synthesized and their invitro inhibitory effects on the human carbonic anhydrase isoenzymes (hCA-I and hCA-II) were evaluated by using the CO2 ... -
Synthesis, structure-activity relationships and biological activity of new isatin derivatives as tyrosinase ınhibitors
Gençer, Nahit; Sönmez, Fatih; Demir, Dudu; Arslan, Oktay; Küçükislamoğlu, Mustafa (Bentham Science Publ Ltd, 2014)A newly series of isatin derivatives (6a-t) containing alkyl/aryl urea groups were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase was purified from ... -
Total synthesis of apigenin glycosides and the effect of these compounds on polyphenol oxidase enzyme activity
Beyaztaş, Serap; Küçükislamoǧlu, Mustafa; Sönmez, Fatih; Nebioğlu, Mehmet; Beşoluk, Şenol; Arslan, Mustafa; Zengin, Mustafa; Arslan, Oktay (Chemical Publishing Co, 2014)We have succeeded in total synthesis of apigenin 7-O-β-D-cellobioside (1a) and apigenin 7-O-β-D-cellobiosyl-4′-O-β-D-glucopyranoside (1c) via four and six steps in a total yield of 56 and 76 % from naringenin (2), respectively. ...
