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Development of carbazole-bearing pyridopyrimidine-substituted urea/thiourea as polyphenol oxidase inhibitors: synthesis, biochemistry, and theoretical studies
Nixha, Arleta Rifati; Ergun, Adem; Gencer, Nahit; Arslan, Oktay; Arslan, Mustafa (Taylor and Francis Ltd, 2019)Polyphenol oxidase (Tyrosinase, PPO) has received considerable attention, since it is the key enzyme in melanin biosynthesis. In this study, we investigated prepared novel carbazole-containing pyridopyrimidine-substituted ... -
Synthesis and evaluation of n-heteroarylsubstituted triazolosulfonamides as carbonic anhydrase inhibitors
Balcı, Ahmet; Arslan, Mustafa; Nixha, Arleta Rifati; Bilen, Çiğdem; Ergün, Adem; Gencer, Nahit (Taylor & Francis Ltd, 2015)A new series of N-heteroarylsubstituted triazolosulfonamide compounds were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and II were evaluated. Compounds (3 a-k) were ... -
Synthesis and theoretical calculations of carbazole substituted chalcone urea derivatives and studies their polyphenol oxidase enzyme activity
Nixha, Arleta Rifati; Arslan, Mustafa; Atalay, Yusuf; Gençer, Nahit; Ergün, Adem; Arslan, Oktay (Taylor & Francis Ltd, 2013)Synthesis of carbazole substituted chalcone urea derivatives and their polyphenol oxidase enzyme activity effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana ...