Yazar "Koçoğlu, Sema Serter" için listeleme
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Betülinik asitin endometrial kanser hücrelerinde MTOR yolağı aracılı olası antikanser etkilerinin araştırılması
Korkusuz, Gözde (Balıkesir Üniversitesi Sağlık Bilimleri Enstitüsü, 2023)Endometrial kanser dünya çapında en yaygın jinekolojik kanserlerden biridir ve her yıl dünya çapında tahminen 42.000 kadın bu kanserden hayatını kaybetmektedir. Günümüzde endometrial kanser için kemoterapi, radyoterapi ve ... -
Effects of monensin and rapamycin combination therapy on tumor growth and apoptosis in a xenograft mouse model of neuroblastoma
Koçoğlu, Sema Serter; Sunay, Fatma Bahar; Akkaya, Pakize Nur (MDPI, 2023)Neuroblastoma is the most common pediatric solid tumor originating from the neural crest. New treatment options are needed to improve treatment outcomes and the survival of patients with neuroblastoma. Monensin is an ... -
Erianin as a promising novel agent in the treatment of neuroblastoma: The anti-cancer effects and underlying molecular mechanisms
Koçoğlu, Sema Serter; Seçme, Mücahit; Sunay, Fatma Bahar (Bentham Science Publishers, 2023)Background: Erianin is an active dibenzyl compound isolated from Dendrobium officinale and Dendrobium chrysotoxum and there are very few studies on molecular mechanisms and drug targets of erianin. In addition, there is ... -
Erianin, a promising agent in the treatment of glioblastoma multiforme triggers apoptosis in U373 and A172 glioblastoma cells
Koçoğlu, Sema Serter; Seçme, Mücahit; Elmas, Levent (Inst Bioloska Istrazivanja Sinisa Stankovic, 2022)Glioblastoma is an aggressive, common and deadly primary intracranial brain tumor in adults. The antitumor activity of erianin, a dibenzyl compound found in Dendrobium chrysotoxum Lindl. extract, has not been previously ... -
Erianinin HT29 kolorektal kanser hücrelerinin proliferasyonu ve koloni oluşumu üzerine etkilerinin araştırılması
Koçoğlu, Sema Serter; Elmas, Levent; Seçme, Mücahit (Seyhan Miğal, 2021)Kolorektal kanser, dünyada kanser ilişkili ölümlerin en yaygın dördüncü sebebidir. Erianin antioksidan ve anti-tümör etkilere sahip Dendrobium ekstraktından elde edilen yeni bir dibenzil bileşiğidir. Bu çalışmada, erianinin ... -
Expression of the ionotropic glutamate receptors on neuronostatin neurons in the periventricular nucleus of the hypothalamus
Koçoğlu, Sema Serter; Çakır, C.; Minbay, Fatma Zehra; Eyigör, Özhan (Via Medica Journals, 2020)Background: Neuronostatin, a newly identified peptide, is accepted as an anorexigenic peptide since it suppresses food intake when given intracerebroventricularly. Although the effect mechanisms of neuronostatin have ... -
Expression of the ionotropic glutamate receptors on neuronostatin neurons in the periventricular nucleus of the hypothalamus
Koçoğlu, Sema Serter; Çakır, Cihan; Minbay, Zehra; Eyigor, Ozhan (Via Medica, 2022)Background: Neuronostatin, a newly identified peptide, is accepted as an anorex- igenic peptide since it suppresses food intake when given intracerebroventricularly. Although the effect mechanisms of neuronostatin have ... -
Glutamate receptor antagonist suppresses the activation of nesfatin-1 neurons following refeeding or glucose administration
Koçoğlu, Sema Serter; Oy, Ceren; Halk, Z.; Çakır, Cihan; Minbay, Zehra; Eyigor, Ozhan (Via Medica, 2022)Background: Nesfatin-1 is a newly identified satiety peptide that has regulatory effects on food intake and glucose metabolism, and is located in the hypothalamic nuclei, including the supraoptic nucleus (SON). In this ... -
Glutamatergic activation of neuronostatin neurons in the periventricular nucleus of the hypothalamus
Koçoğlu, Sema Serter; Yurtseven, Duygu Gök; Çakır, Cihan; Minbay, Zehra; Eyigor, Özhan (MDPI, 2020)Neuronostatin, a newly identified anorexigenic peptide, is present in the central nervous system. We tested the hypothesis that neuronostatin neurons are activated by feeding as a peripheral factor and that the glutamatergic ... -
Immunohistochemical evidence for glutamatergic regulation of nesfatin-1 neurons in the rat hypothalamus
Yurtseven, Duygu Gök; Koçoğlu, Sema Serter; Minbay, Zehra; Eyigor, Özhan (MDPI, 2020)Nesfatin-1, identified as an anorexigenic peptide, regulates the energy metabolism by suppressing food intake. The majority of nesfatin-1-synthesizing neurons are concentrated in various hypothalamic nuclei, especially in ... -
Investigation of the anticancer mechanism of monensin via apoptosis-related factors in SH-SY5Y neuroblastoma cells
Koçoğlu, Sema Serter; Oy, Ceren; Seçme, Mücahit; Sunay, Fatma Bahar (Wiley, 2023)Monensin is an ionophore antibiotic that inhibits the growth of cancer cells. The aim of this study was to investigate the apoptosis-mediated anticarcinogenic effects of monensin in SH-SY5Y neuroblastoma cells. The effects ... -
Investigation of the TLR4 and IRF3 signaling pathway-mediated effects of monensin in colorectal cancer cells
Seçme, Mücahit; Koçoğlu, Sema Serter (Springer, 2023)Monensin is an ionophore antibiotic isolated from Streptomyces cinnamonensis with very strong antibacterial and antiparasitic effects. Although monensin is known to exhibit anticancer activity in different cancer types, ... -
Monensin, an antibiotic isolated from streptomyces cinnamonensis, regulates human neuroblastoma cell proliferation via the PI3K/AKT signaling pathway and acts synergistically with rapamycin
Koçoğlu, Sema Serter; Seçme, Mücahit; Oy, Ceren; Korkusuz, Gözde; Elmas, Levent (MDPI, 2023)Neuroblastoma is the most common extracranial childhood tumor and accounts for approximately 15% of pediatric cancer-related deaths. Further studies are needed to identify potential therapeutic targets for neuroblastoma. ... -
Monensinin glioblastoma multiformede kaspaz-10 aracılı apoptoz üzerine etkileri
Koçoğlu, Sema Serter; Seçme, Mücahit (Seyhan Miğal, 2021)Glioblastoma multiforme (GBM), en kötü huylu primer merkezi sinir sistemi tümörüdür. Şu anda, GBM için iyileştirici tedavi seçenekleri yoktur ve 5 yıllık hayatta kalma oranı %5’den daha azdır. Monensin, ‘’Streptomyces ...
