Yazar "Kant, Melis" için listeleme
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Alterations in levels of 8-Oxo-2 '-deoxyguanosine and 8-Oxoguanine DNA glycosylase 1 during a current episode and after remission in unipolar and bipolar depression
Ceylan, Deniz; Yılmaz, Selda; Tuna, Gamze; Kant, Melis; Er, Ayşe; Ildız, Ayşegül; Verim, Burcu; Akış, Merve; Akan, Pınar; Islekel, Hüray (Pergamon-Elsevier Science Ltd, 2020)Introduction: Previous studies showed significant increases in DNA base damage markers and significant alterations in base excision repair enzymes in patients with unipolar and bipolar depression. We aimed to investigate ... -
Assessment of plasma-free cortisol concentrations by LC-MS/MS in patients with autonomous cortisol secretion
Yener, Serkan; Tuna, Gamze; Kant, Melis; Akış, Merve; Kara, Özlem; Kalas, Büşra; Barış, Mustafa; Islekel, Gül Hüray (Georg Thieme Verlag KG, 2021)Autonomous cortisol secretion (ACS) of an adrenal incidentaloma (AI) is associated with mild cortisol excess that could result in poor metabolic and cardiovascular outcomes. The biological activity of glucocorticoids depends ... -
Association between early oxidative DNA damage and iron status in women with diabetes mellitus
Erbağcı, Mehmet Oğuz; Tuna, Gamze; Bekar, Nazlı Ecem Dal; Akış, Merve; Kant, Melis; Altunyurt, Sabahattin; İşlekel, Gül Hüray (Pergamon-Elsevier Science Ltd, 2021)This study aims to assess the relationship between oxidative DNA damage and iron status in women with gestational diabetes mellitus (GDM) compared to those with normal glucose tolerance in the first and the second trimesters ... -
Development and validation of liquid chromatography/stable isotope-dilution tandem mass spectrometry method for measurement of dexamethasone, total cortisol and free cortisol in human plasma
Tuna, Gamze; Kant, Melis; Akış, Merve; Yener, Serkan; İşlekel, Gül Hüray (Dokuz Eylul Univ Inst Health Sciences, 2023)Background Cortisol plays a role in the regulation of metabolic homeostasis. Dexamethasone is a powerful synthetic glucocorticoid that acts as an anti-inflammatory and immunosuppressive agent. Plasma free cortisol, which ... -
Effects of paricalcitol on hydrogen peroxide-induced oxidative damage in human umbilical vein endothelial cells through vitamin D receptor signaling
Akış, Merve; Kant, Melis; Yüce, Zeynep; Dizdaroğlu, Miral; İşlekel, Hüray (Wiley, 2018)Oxidative DNA damage is caused by the imbalance betweenreactive oxygen species (ROS) and the antioxidants in cells.Accumulation of DNA damage might lead to a variety of muta-tions and consequently to genomic instability. ... -
Functional vitamin B12 deficiency in phenylketonuria patients and healthy controls: An evaluation with combined indicator of vitamin B12 status as a biochemical index
Akış, Merve; Kant, Melis; Işık, İshak; Kısa, Pelin Teke; Köse, Engin; Arslan, Nur; Islekel, Hüray (Sage Publications, 2020)Background Vitamin B12 deficiency frequently appears in phenylketonuria patients having a diet poor in natural protein. The aims of this study were to evaluate vitamin B12 status in phenylketonuria patients by using combined ... -
Oxidation induced DNA damage and base excision repair during a current episode and after remission in bipolar and unipolar depression
Ceylan, Deniz; Yılmaz, Selda; Tuna, Gamze; Kant, Melis; Er, Ayşe; Ildız, Ayşegül; Verim, Burcu; Akış, Merve (Wiley, 2020)Introduction: Emerging evidence suggest a central role of DNA damage/repair mechanisms in pathogenesis of mood disorders. We aimed to understand DNA damage/repair during a current depres-sive episode and after remission ...
