Yazar "Işıldar, Başak" için listeleme
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Comparative analysis of effects of conditioned mediums obtained from 2D or 3D cultured mesenchymal stem cells on kidney functions of diabetic rats: Early intervention could potentiate transdifferentiation of parietal epithelial cell into podocyte precursors
Özkan, Serbay; Işıldar, Başak; Şahin, Hakan; Saygı, Halil İbrahim; Konukoğlu, Dildar; Koyutürk, Meral (Elsevier, 2024)Aim: The secretome of mesenchymal stem cells (MSCs) could be a potential therapeutic intervention for diabetes and associated complications like nephropathy. This study aims to evaluate the effects of conditioned ... -
Effects of chronically exogenous oxytocin on ovary and uterus: A comparison of intraperitoneal and intranasal administration
Şentürk, Gözde Erkanlı; Sezer, Zehra; Şahin, Hakan; Işıldar, Başak; Abdulova, Aynur (Elsevier, 2023)Oxytocin (OT) has been studied as a therapeutic neuropeptide in various diseases, but its effect on the ovary and uterus is not fully known. This study investigates the effects of intranasal and intraperitoneal OT ... -
Effects of conditioned mediums collected from 2d or 3d cultured mscs on kidney functions of rats with autoimmune diabetes induced with streptozocin
Özkan, Serbay; Işıldar, Başak; Şahin, Hakan; Saygı, Halil İbrahim; Konukoğlu, Dildar; Koyutürk, Meral (Oxford Univ Press, 2023)Background and Aims: The main mechanism of therapeutic action of mesenchymal stem cells (MSCs) could be resulted from their secretome content rather than their direct differentiation into damaged cells [1, 2]. Preconditioning ... -
Evaluation of mesenchymal stem cells proconditioned with dimethyloxalylglycine with respect to changes in cellular and secretory profiles
Özkan, S.; Olcar, H.; Işıldar, Başak; Ercin, M.; Gezginci-Oktayoglu, S.; Koyuturk, M. (Elsevier Sci Ltd, 2023)Özet bilgisi yok. -
Preconditioning of human umbilical cord mesenchymal stem cells with a histone deacetylase inhibitor: Valproic acid
Işıldar, Başak; Özkan, Serbay; Koyutürk, Meral (Galenos Publishing House, 2024)Background: Mesenchymal stem cells (MSCs) play a key role in regenerative medicine due to their capacity to differentiate into multiple cell lines, regulate the immune system, and exert paracrine effects. The therapeutic ... -
Preconditioning of human umbilical cord mesenchymal stem cells with deferoxamine potentiates the capacity of the secretome released from the cells and promotes immunomodulation and beta cell regeneration in a rat model of type 1 diabetes
Işıldar, Başak; Özkan, Serbay; Şahin, Hakan; Erçin, Merve; Oktayoğlu, Selda Gezginci; Koyutürk, Meral (Elsevier, 2024)This study aimed to examine the effects of the secretome released by human umbilical cord-mesenchymal stem cells (MSC) as a result of preconditioning with deferoxamine (DFX), a hypoxia mimetic agent, on type 1 diabetes ... -
Therapeutic effects of conditioned medium from human umbilical cord mesenchymal stem cells with/without deferoxamine-preconditioning on the severe type 1 diabetes model in rats
Işıldar, Başak; Özkan, S.; Şahin, H.; Ercin, M.; Gezginci-Oktayoglu, S.; Koyuturk, M. (Elsevier Sci Ltd, 2023)Background & Aim: Type 1 diabetes (T1D) is a T-cell-mediated autoimmune disease characterized by the irreversible destruction of pancreatic -cells. Impaired T-cell balance and cytokine production play a synergistic role ... -
Therapeutic potential of mesenchymal stem cell-derived conditioned medium for diabetes mellitus and related complications
Işıldar, Başak; Özkan, Serbay; Koyutürk, Meral (Wiley, 2023)Diabetes mellitus (DM) is one of the most life-threatening metabolic disorders, with 9% of the global prevalence, and it is estimated to be rising to 12.2% in 2045. Currently, there is no definitive treatment for DM. ...
