Yazar "Gencer, Nahit" için listeleme
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An alternative purification method for human serum paraoxonase 1 and its interactions with anabolic compounds
Demir, Dudu; Gencer, Nahit; Arslan, Oktay (Taylor & Francis Ltd, 2016)In this study, an alternative purification method for human paraoxonase 1 (hPON1) enzyme was developed using two-step procedures, namely, ammonium sulfate precipitation and Sepharose-4B-l-tyrosine-3-aminophenantrene ... -
Determination of paraoxonase 1 activity and phenotype distribution in cervical disk herniation patients
Adilay, Utku; Katar, Salim; Çıkrıkçı, Kübra; Gencer, Nahit (Balıkesir Üniversitesi, 2024)Determination of Paraoxonase 1 Activity and Phenotype Distribution in Cervical Disk Herniation Patients Abstract Objectives: Cervical disk herniation (CDH) is a common disease that usually develops as a result of intervertebral ... -
Development of carbazole-bearing pyridopyrimidine-substituted urea/thiourea as polyphenol oxidase inhibitors: synthesis, biochemistry, and theoretical studies
Nixha, Arleta Rifati; Ergun, Adem; Gencer, Nahit; Arslan, Oktay; Arslan, Mustafa (Taylor and Francis Ltd, 2019)Polyphenol oxidase (Tyrosinase, PPO) has received considerable attention, since it is the key enzyme in melanin biosynthesis. In this study, we investigated prepared novel carbazole-containing pyridopyrimidine-substituted ... -
The effect of total anthocyanins extracted from sweet cherry cultivars on carbonic anhydrases and antioxidant activity
Sönmez, Fatih; Güneşli, Zuhal; Demir, Taki; Çıkrıkcı, Kübra; Ergün, Adem; Gencer, Nahit; Arslan, Oktay (Springer, 2022)Total anthocyanins were extracted from eleven sweet cherry cultivars grown in Sakarya, Turkey. In vitro inhibition effects of extracted total anthocyanins on purified carbonic anhydrase I and II were investigated by using ... -
The effects of anti-epileptic drugs on human erythrocyte carbonic anhydrase I and II isozymes
Koç, Emine Rabia; Erken, Gülten; Bilen, Çiğdem; Sackes, Zübeyde; Gencer, Nahit (Taylor & Francis Ltd, 2014)Carbonic anhydrase (CA) is an enzyme which plays a role in various homeostatic mechanisms, such as acid-base balance and electrolyte secretion in a various tissues. This study was aimed at determining and comparing possible ... -
The effects of bronchodilator drugs and antibiotics used for respiratory infection on human erythrocyte carbonic anhydrase I and II isozymes
Sarıoğlu, Nurhan; Bilen, Çiğdem; Saçkes, Zübeyde; Gencer, Nahit (Taylor & Francis Ltd, 2015)Carbonic anhydrase (CA) is an enzyme which plays role/roles in various homeostatic mechanisms, such as the acid-base balance and electrolyte secretion in various tissues. This study aimed to determine and to compare possible ... -
The effects of cardiac drugs on human erythrocyte carbonic anhydrase I and II isozymes
Argan, Onur; Çıkrıkçı, Kübra; Baltacı, Aybike; Gencer, Nahit (Taylor and Francis Ltd, 2020)Cardiovascular diseases are the leading cause of mortality worldwide. In recent years, the relationship between carbonic anhydrase inhibitors and atherosclerosis has attracted attention. In this study, we aimed to determine ... -
The effects of ex vivo ozone treatment on erythrocyte carbonic anhydrase enzyme
Erken, Gülten; Erken, Haydar Ali; Bilen, Çiğdem; Gencer, Nahit (Wiley-Blackwell, 2015)AIM: Medical ozone generates beneficial effects by stimulating the endogenous antioxidant systems. Carbonic anhydrases (CAs, EC 4.2.1.1.) are metalloenzymes and play a significant role in acid-base regulation. The aim of ... -
The effects of ex vivo ozone treatment on human erythrocyte carbonic anhydrase enzyme
Erken, Gülten; Erken, Haydar Ali; Bilen, Ciğdem; Gencer, Nahit (Taylor & Francis Ltd, 2018)Ozone autohemotherapy is used in the treatment of some diseases. Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes and play a role in homeostatic mechanisms. The aim of this study was to investigate the effects of ... -
Effects of four pesticides on broilers glutathione-s-transferase activity
Arslan, Mikail; Tak, Tuğba; Ergün, Adem; Gencer, Nahit; Arslan, Oktay (Parlar Scientific Publications (P S P), 2018)GST is the most important detoxifying enzyme of environmental pollutants, such as carcinogenic matters, heavy metals, some of drugs and pesticides. In this study, hydrophobic gel having a chemical structure of Sepharose ... -
The effects of two different antihipertansive drugs as beta blockers-adrenergic receptor antagonists on hca1 and hca2 isozymes in obstructive sleep apnea patients and control group
Gökçe, B.; Gencer, Nahit; Sarıoğlu, N; Erik, S. (Wiley, 2017)The catalytic function of the enzyme carbonic anhydrase (CA) plays a fundamental role in carbon dioxide (CO2), proton (H+), and bicarbonate (HCO3 ) homeostasis. A specific role of CA in respiration and ventilatory ... -
Evaluation of carbonic anhydrase and paraoxonase inhibition activities and molecular docking studies of highly water-soluble sulfonated phthalocyanines
Güzel, Emre; Sönmez, Fatih; Erkan, Sultan; Çıkrıkçı, Kübra; Ergun, Adem; Gencer, Nahit; Arslan, Oktay; Koçak, Makbule Burkut (Scientific Technical Research Council Turkey-Tubitak, 2020)The investigation of carbonic anhydrase and paraoxonase enzyme inhibition properties of water-soluble zinc and gallium phthalocyanine complexes (1 and 2) are reported for the first time. The binding of p-sulfonylphenoxy ... -
Functionalized imidazolium and benzimidazolium salts as paraoxonase 1 inhibitors: Synthesis, characterization and molecular docking studies
Karataş, Mert Olgun; Uslu, Harun; Alıcı, Bülent; Gökçe, Başak; Gencer, Nahit; Arslan, Oktay; Arslan, N. Burcu; Özdemir, Namık (Pergamon-Elsevier Science Ltd, 2016)Paraoxonase (PON) is a key enzyme in metabolism of living organisms and decreased activity of PON1 was acknowledged as a risk for atherosclerosis and organophosphate toxicity. The present study describes the synthesis, ... -
Impact of carbazole p-lactam derivatives on paraoxonase-1 activity
Gökçe, Başak; Bytyqi-Damoni, Arlinda; Genç, Hayriye; Zengin, Mustafa; Gencer, Nahit; Arslan, Oktay (Parlar Scientific Publications, 2017)Paraoxonase 1 (PON1) is an antioxidant enzyme associated with high-density lipoproteins (HDL). PON1 has the ability to inhibit lipid peroxides and to hydrolyze a wide variety of substrates such as esters, thioesters, ... -
In vitro activation of paraoxonase 1 by steroids: An experimental, molecular docking, and molecular modelling study
Deveci, Ufuk; Çıkrıkcı, Kübra; Kuru, Ali; Yıldırım, Kudret; Tilahun, Muhammed Muhammed; Gencer, Nahit (John Wiley and Sons Inc, 2024)Paraoxonase 1 (PON1) is an antioxidant enzyme that prevents lipid oxidation by hydrolysing lipid peroxides in the oxidised low-density lipoprotein (LDL) structure, bound to high-density lipoprotein (HDL) in serum, and ... -
In vitro effects of estrogen and progesterone containing drugs on human erythrocyte carbonic anhydrase I and II isozymes in women smokers and nonsmokers
Taşkın, Mine İslimye; Bilen, Çiğdem; Ergün, Adem; Gencer, Nahit; İnceboz, Ümit (Elsevier Taiwan, 2015)Background: Carbonic anhydrases (CAs), a group of metalloenzymes, are involved in numerous physiological and pathological processes such as acid base balance, gluconeogenesis, lipogenesis, ureagenesis, electrolyte secretion ... -
In vitro effects of thirty-eight cardiac drugs on human serum paraoxonase
Argan, Onur; Çıkrıkcı, Kübra; Uslu, Harun; Gencer, Nahit (Wiley, 2022)In this study, the effects of 38 commonly used cardiac drugs on the human paraoxonase (PON1) were investigated. PON1 was purified from human serum blood by ammonium sulfate precipitation (60%-80%) and hydrophobic interaction ... -
In vitro efficacy of some cattle drugs on bovine serum paraoxonase 1 (PON1) activity
Arslan, Mikail; Gencer, Nahit; Arslan, Oktay; Güler, Özen Özensoy (Informa Healthcare, 2012)Serum paraoxonase 1 (EC 3.1.8.1, PON1), a calcium-associated enzyme, has an ability to hydrolyze organophosphate compounds. Related to this property, PON1 has a critical role in antioxidant mechanisms. It is well-known ... -
In vitro inhibition effect of some coumarin compounds on purified human serum paraoxonase 1 (PON1)
Gökce, Başak; Gencer, Nahit; Arslan, Oktay; Karataş, Mert Olgun; Alıcı, Bülent (Taylor & Francis Inc, 2016)Human serum paraoxonase 1 (PON1; EC 3.1.8.1) is a high-density lipoprotein associated, calcium-dependent enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect the low-density lipoprotein ... -
In vitro inhibition effects on erythrocyte carbonic anhydrase I and II and structure-activity relationships of cumarylthiazole derivatives
Kurt, Belma Zengin; Sönmez, Fatih; Gökçe, Başak; Ergün, Adem; Gencer, Nahit; Demir, Taki; Arslan, Oktay; Küçükislamoğlu, Mustafa (Maik Nauka, 2016)Coumarin and heterocyclic compounds incorporating urea have clinical applications as antiepileptics, diuretics, and antiglaucoma agents due to their carbonic anhydrase inhibitory properties. We investigated inhibition of ...
