Yazar "Gençer, Nahit" için listeleme
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Activity-pH-inhibition interaction on purify $PON1 _{Q192} and PON1 _{R192}$
Gençer, Nahit; Arslan, Oktay (2009)Human serum paraoxonase (PON1, EC 3.1.8.1.) is a high-density lipid (HDL)-associated, calcium-dependent enzyme; its physiological substrates are not known. PON1 exists in 2 major polymorphic forms: Q (glutamine) or R ... -
Afinite kromatografisi yöntemi ile saflaştırılan karbonik anhidraz (I-II) izoenzimleri üzerine bazı pestisitlerin in vitro etkilerinin araştırılması
Gençer, Nahit; Baltacı, Aybike; Çıkrıkcı, Kübra (Doç. Dr. Fikret TÜRKAN, 2024)Bu çalışmanın amacı; çevre ve insan sağlığı için toksisitesi yüksek olan bazı pestisitlerin hidrataz aktivite yöntemi kullanılarak karbonik anhidraz izoenzimleri (hCA I ve II) üzerine etkilerini araştırmaktır. İnsan kan ... -
Age and diet influence the composition of venom from the endoparasitic wasp Pimpla turionellae L. (Hymenoptera : Ichneumonidae)
Uçkan, Fevzi; Ergin, Ekrem; Rivers, David B.; Gençer, Nahit (Wiley-Liss, 2006)Venom from the endoparositic wasp Pimpla turionellae L. (Hymenoptera: Ichneumonidae) was found to contain a complex mixture of biogenic amines, noradrenalin, phospholipase 13, and several proteins and peptides. The amount ... -
Alkalen fosfataz enziminin saflaştırılması ve bazı ilaçlara karşı afinitesinin araştırılması
Bilen, Çiğdem (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2015)Bu çalışmada, fosfat metabolizmasında önemli role sahip olan Alkalen Fosfatazın (ALP), sütte pastörizasyon belirteci olarak kullanılması gerekçesiyle sütte bulunan izoformu biyokimyasal yöntemlerle saflaştırılmış ve bazı ... -
An alternative purification method for human serum paraoxonase 1 and its interaction with methidathion
Gençer, Nahit; Yavuz, Emre (Taylor & Francis Ltd, 2017)In this study, an alternative purification method for human Paraoxonase 1 (hPON1) enzyme was developed using two-step procedures, namely ammonium sulphate precipitation and Sepharose-4B-L-tyrosine-1-aminoanthracene hydrophobic ... -
Amphenicol and macrolide derived antibiotics inhibit paraoxonase enzyme activity in human serum and human hepatoma cells (HepG2) in vitro
Sinan, Selma; Köçkar,Feray; Gençer, Nahit; Yıldırım, Hatice Kalkan; Arslan, Oktay (Maik Nauka/Interperiodıca/Springer, 2006)Human serum paraoxonase (hPON 1) was separately purified by ammonium sulfate precipitation and hydrophobic interaction chromatography The in vitro effects of commonly used antibiotics, namely clarithromycin and chloramphenicol, ... -
Antioxidant properties of various olive cultivars
Gençer, Nahit; Sinan, Selma; Arslan, Oktay (2009)Virgin olive oil is a typical component of the Mediterranean diet, consumed unrefined and rich in important molecules, such as minor polar compounds (tyrosol, ferulic acid and caffeic acid). These molecules not only influence ... -
Antipsychotic agents screened as human carbonic anhydrase I and II inhibitors
Erzengin, Mahmut; Bilen, Çiğdem; Ergün, Adem; Gençer, Nahit (Informa Healthcare, 2014)The antipsychotic drugs currently used to treat schizophrenia can be divided into two distinct classes, typical and atypical antipsychotics. Many drug molecules are enzyme inhibitors that bind reversibly or irreversibly ... -
Association of human serum paraoxonase-1 with some respiratory drugs
Gökçe, Başak; Sarıoğlu, Nurhan; Gençer, Nahit; Arslan, Oktay (Wiley, 2019)In this study, we investigated the effects of certain respiratory drugs, which are mainly used on human serum paraoxonase-1 (hPON1; EC 3.1.8.1). hPON1 was purified from human serum, with 354.91 fold and 45% yield by using ... -
Bazı pestisitlerin karbonik anhidraz izoenzimleri üzerine etkilerinin araştırılması
Baltacı, Aybike (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2021)u çalışmada insan eritrositlerinden Karbonik anhidraz izoenzimleri saflaştırıldı ve bazı pestisitlerin bu enzim üzerine inhibisyon etkileri araştırıldı. Enzim Sepharose-4B-4-(6-Amino-hekziloksi)-benzensulfonamit kimyasal ... -
Bazı steroid türevlerinin paraoksonaz enzimine karşı afinitesinin araştırılması
Deveci, Ufuk (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2024)Bu tez çalışmasında; ilk önce Sefaroz 4B-L-tirozin-naftilamin kimyasal yapısına sahip hidrofobik jel kullanılarak insan serumundan PON1 (hPON1) enzimi saflaştırılmıştır. Daha sonra saf hPON1 enzimine karşı bazı steroid ... -
Characterization of mendo (Antriscus nemorosa) and Mentha species polyphenol oxidase
Savaş, Elif; Gençer, Nahit; Sayın, Murat; Arslan, Oktay (Blackwell Publishing, 2008)Introduction: Polyphenol oxidases (PPO) (EC 1.14.18.1) are very important enzymes in food industry for their involvement in the enzymatic browning of edible plants. Herby cheese, a semi-hard, salty and herb added, is ... -
Characterization of polyphenoloxidase from wild pear (Pyrus elaegrifolia)
Yerlitürk, Fatma Ülker; Arslan, Oktay; Sinan, Selma; Gençer, Nahit; Güler, Özen Özensoy (Wiley, 2008)Wild pear polyphenoloxidase (PePPO) was extracted and purified using a Sepharose 4B-L-tyrosine-p-amino benzoic acid affinity column. Optimum conditions for pH, temperature and heat inactivation were determined. At the ... -
Effect of 3-amino-1,2,4-triazole-5-carboxylic acid on human blood erythrocyte catalase
Çıkrıkcı, Kübra; Gençer, Nahit (Barbaros Akkurt, 2024)Catalase is an antioxidant enzyme with great therapeutic potential that scavenges hydrogen peroxide, a reactive oxygen species produced during cellular metabolism. Substances containing 1,2,4- triazole structures are ... -
Effect of ammonium sulphate on the activities of paraoxonase isoenzymes Q and R
Gençer, Nahit; Arslan, Oktay (Asian Journal of Chemistry, 2011)Paraoxonase isoenzymes exists in 2 polymorphic forms, Q (glutamine) or R (arginine) at codon 192. The Q isoform has a higher activity for hydrolyze of diazoxon, sarin and soman; whereas the R isoform has a higher activity ... -
Effects of some antibiotics on paraoxonase from human serum in vitro and from mouse serum and liver in vivo
Sinan, Selma; Köçkar, Feray; Gençer, Nahit; Yıldırım, Hatice; Arslan, Oktay (Pharmaceutical Soc Japan, 2006)Paraoxonase (PON1, EC 3.1.8.1) is an esterase protein which plays multifunctional role in metabolism. Therefore, in this study the effects of commonly used antibiotics, namely sodium ampicillin, ciprofloxacin, rifamycin ... -
Effects of some metals on paraoxonase activity from shark Scyliorhinus canicula
Sayın, Demet; Çakır, Dilek Türker; Gençer, Nahit; Arslan, Oktay (Taylor & Francis Ltd, 2012)Paraoxonase (PON) is an organophosphate hydrolyser enzyme which also has antioxidant properties in metabolism. Due to its crucial functions, the inhibition of the enzyme is undesirable and very dangerous. PON enzyme activity ... -
Evaluation of in vitro effects of some analgesic drugs on erythrocyte and recombinant carbonic anhydrase I and II
Gökçe, Başak; Gençer, Nahit; Arslan, Oktay; Türkoğlu, Sümeyye Aydoğan; Alper, Meltem; Köçkar, Feray (Informa Healthcare, 2012)The in vitro effects of the injectable form of analgesic drugs, dexketoprofen trometamol, dexamethasone sodium phosphate, metamizole sodium, diclofenac sodium, thiocolchicoside, on the activity of purified human carbonic ... -
Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors
Sönmez, Fatih; Sevmezler, Sedat; Atahan, Alparslan; Ceylan, Mustafa; Demir, Dudu; Gençer, Nahit; Arslan, Oktay; Küçükislamoğlu, Mustafa (Pergamon-Elsevier Science Ltd, 2011)A newly series of 4-(phenylurenyl) chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. ... -
Extraction and biological activity of total anthocyanins from sweet cherry cultivars as polyphenol oxidase inhibitors
Demir, Taki; Sönmez, Fatih; Bilen, Çiğdem; Gençer, Nahit (WFL Publisher Ltd., 2013)Total anthocyanins were extracted from six sweet cherry cultivars grown in Sakarya, Turkey, and their inhibitory effects on the diphenolase activity of banana polyphenol oxidase (PPO) were evaluated. The PPO was purified ...
