Yazar "Gökçe, Başak" için listeleme
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Association of human serum paraoxonase-1 with some respiratory drugs
Gökçe, Başak; Sarıoğlu, Nurhan; Gençer, Nahit; Arslan, Oktay (Wiley, 2019)In this study, we investigated the effects of certain respiratory drugs, which are mainly used on human serum paraoxonase-1 (hPON1; EC 3.1.8.1). hPON1 was purified from human serum, with 354.91 fold and 45% yield by using ... -
Catalase, carbonic anhydrase and xanthine oxidase activities in patients with mycosis fungoides
Cengiz, Fatma Pelin; Beyaztaş, Serap; Gökçe, Başak; Arslan, Oktay; Güler, Özen Özensoy (Taylor & Francis Ltd, 2014)Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. In several studies the relationship between catalase (CAT), human cytosolic carbonic anhydrases (CA; hCA-I and hCA-II) and xanthine oxidase (XO) ... -
Evaluation of in vitro effects of some analgesic drugs on erythrocyte and recombinant carbonic anhydrase I and II
Gökçe, Başak; Gençer, Nahit; Arslan, Oktay; Türkoğlu, Sümeyye Aydoğan; Alper, Meltem; Köçkar, Feray (Informa Healthcare, 2012)The in vitro effects of the injectable form of analgesic drugs, dexketoprofen trometamol, dexamethasone sodium phosphate, metamizole sodium, diclofenac sodium, thiocolchicoside, on the activity of purified human carbonic ... -
Functionalized imidazolium and benzimidazolium salts as paraoxonase 1 inhibitors: Synthesis, characterization and molecular docking studies
Karataş, Mert Olgun; Uslu, Harun; Alıcı, Bülent; Gökçe, Başak; Gencer, Nahit; Arslan, Oktay; Arslan, N. Burcu; Özdemir, Namık (Pergamon-Elsevier Science Ltd, 2016)Paraoxonase (PON) is a key enzyme in metabolism of living organisms and decreased activity of PON1 was acknowledged as a risk for atherosclerosis and organophosphate toxicity. The present study describes the synthesis, ... -
Impact of carbazole p-lactam derivatives on paraoxonase-1 activity
Gökçe, Başak; Bytyqi-Damoni, Arlinda; Genç, Hayriye; Zengin, Mustafa; Gencer, Nahit; Arslan, Oktay (Parlar Scientific Publications, 2017)Paraoxonase 1 (PON1) is an antioxidant enzyme associated with high-density lipoproteins (HDL). PON1 has the ability to inhibit lipid peroxides and to hydrolyze a wide variety of substrates such as esters, thioesters, ... -
In vitro inhibition effects on erythrocyte carbonic anhydrase I and II and structure-activity relationships of cumarylthiazole derivatives
Kurt, Belma Zengin; Sönmez, Fatih; Gökçe, Başak; Ergün, Adem; Gencer, Nahit; Demir, Taki; Arslan, Oktay; Küçükislamoğlu, Mustafa (Maik Nauka, 2016)Coumarin and heterocyclic compounds incorporating urea have clinical applications as antiepileptics, diuretics, and antiglaucoma agents due to their carbonic anhydrase inhibitory properties. We investigated inhibition of ... -
Inhibition of paraoxonase 1 by coumarin-substituted N-heterocyclic carbene silver(I), ruthenium(II) and palladium(II) complexes
Karataş, Mert Olgun; Çalgın, Gamze; Alıcı, Bülent; Gökçe, Başak; Gencer, Nahit; Tok, Tuğba Taşkın; Arslan, Oktay; Kılıç-Cıkla, Işın (Wiley, 2019)We synthesized three coumarin-substituted benzimidazolium chlorides and their silver(I), ruthenium(II) and palladium(II) N-heterocyclic carbene (NHC) complexes. All compounds were characterized using appropriate spectroscopic ... -
Karbazol ß-laktam türevlerinin paraoksonaz enzimi üzerine etkilerinin araştırılması
Gökçe, Başak (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2013)Paraoksonaz (PON1), arilesteraz, paraoksonaz ve laktonaz aktivitesine sahip bir ester hidrolazdır. Detoksifikasyon ve antioksidan aktivitesi ile metabolizmada önemli fizyolojik fonksiyona sahip olan paraoksonaz (PON1) ... -
Some coumarins and benzoxazinones as potent paraoxonase 1 inhibitors
Karataş, Mert Olgun; Uslu, Harun; Alıcı, Bülent; Gökçe, Başak; Gençer, Nahit; Arslan, Oktay (Taylor & Francis Inc, 2016)In this study, we aimed to investigate the effect of some coumarin and benzoxazinone derivatives on the activity of human PON1. Human serum paraoxonase 1 was purified from fresh human serum blood by two-step procedures ... -
Synthesis of carbazole bearing pyridopyrimidine-substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity
Rifati-Nixha, Arleta; Arslan, Mustafa; Gencer, Nahit; Çıkrıkcı, Kübra; Gökçe, Başak (Wiley, 2019)The synthesis of carbazole containing pyridopyrimidine-substituted sulfonamide derivatives (3a-i) and their inhibitory effects on human carbonic anhydrase (hCA) I and II were studied. Spectral data and elemental analysis ... -
Synthesis, characterization, carbonic anhydrase inhibitor activity, and docking studies of phenylthiazol-2(3h)-ylidene-isoquinoline-5-amine derivatives
Berber, Nurcan; Şahutoğlu, Arif Sercan; Gökçe, Başak; Çıkrıkçı, Kübra; Gençer, Nahit (Elsevier, 2023)Phenylthiazol-2(3h)-ylidene-isoquinoline-5-amine derivatives(5a-r) were easily prepared from 5-aminoisoquinoline, thioisocyanate, and phenacyl bromide derivatives in the presence of triethylamine in tetrahydrofuran (THF), ...
