Yazar "Arslan, Oktay" için listeleme
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Abdominal aort anevrizmalı hastalarda serum paraoksonaz aktivitesinin araştırılması
Reyhan, Miray (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2016)İnsan serum paraoksonaz (PON1) enzimi vücutta antioksidan özelliği gösteren en önemli enzimlerden biridir. Bu enzim sayesinde vücutta oluşan serbest radikaller etkisiz hale gelmektedir. Abdominal aort anevrizması, karın ... -
Activity-pH-inhibition interaction on purify $PON1 _{Q192} and PON1 _{R192}$
Gençer, Nahit; Arslan, Oktay (2009)Human serum paraoxonase (PON1, EC 3.1.8.1.) is a high-density lipid (HDL)-associated, calcium-dependent enzyme; its physiological substrates are not known. PON1 exists in 2 major polymorphic forms: Q (glutamine) or R ... -
Affinity effects of some antibiotics on xanthine oxidase enzyme activities in vitro
Beyaztaş, Serap; Arslan, Oktay (2011)Ksantin oksidaz (KO), pürin katabolizmasının en son enzimidir. KO, amonyum sülfat çöktürmesi ve afinite kromatografisi ile saflaştırıldıktan sonra tıpta yaygın olarak kullanılan antibiyotiklerin etkileri incelendi. Etkisi ... -
Affinity to some plant growth regulators on human erythrocytes Cytosolic Carbonic anhydrase I and II
Bayaztaş, Serap; Arslan, Oktay (2009)The purpose of this study was to investigate the in vitro effects of four commonly used plant growth regulators (PGRs): indole-3-acetic acid, indole-3-butyric acid, gibberellic acid and kinetin on human carbonic anhydrase ... -
An alternative purification method for human serum paraoxonase 1 and its interactions with anabolic compounds
Demir, Dudu; Gencer, Nahit; Arslan, Oktay (Taylor & Francis Ltd, 2016)In this study, an alternative purification method for human paraoxonase 1 (hPON1) enzyme was developed using two-step procedures, namely, ammonium sulfate precipitation and Sepharose-4B-l-tyrosine-3-aminophenantrene ... -
Amphenicol and macrolide derived antibiotics inhibit paraoxonase enzyme activity in human serum and human hepatoma cells (HepG2) in vitro
Sinan, Selma; Köçkar,Feray; Gençer, Nahit; Yıldırım, Hatice Kalkan; Arslan, Oktay (Maik Nauka/Interperiodıca/Springer, 2006)Human serum paraoxonase (hPON 1) was separately purified by ammonium sulfate precipitation and hydrophobic interaction chromatography The in vitro effects of commonly used antibiotics, namely clarithromycin and chloramphenicol, ... -
Antioxidant properties of various olive cultivars
Gençer, Nahit; Sinan, Selma; Arslan, Oktay (2009)Virgin olive oil is a typical component of the Mediterranean diet, consumed unrefined and rich in important molecules, such as minor polar compounds (tyrosol, ferulic acid and caffeic acid). These molecules not only influence ... -
Association of human serum paraoxonase-1 with some respiratory drugs
Gökçe, Başak; Sarıoğlu, Nurhan; Gençer, Nahit; Arslan, Oktay (Wiley, 2019)In this study, we investigated the effects of certain respiratory drugs, which are mainly used on human serum paraoxonase-1 (hPON1; EC 3.1.8.1). hPON1 was purified from human serum, with 354.91 fold and 45% yield by using ... -
Balıkesir yöresinde yetişen bazı origanum L.(lamiaceae) taksonlarının (origanum onites L.ve origanum vulgare L.ssp.hirtum(link.) letswaart) çevre faktörleriyle olan ilişkilerinin ve polifenoloksidaz aktivitesinin belirlenmesi
Doğan, Serap (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2002)Bu çalışmada Origanum onites ve Origanum vulgare ssp. hirtum taksonlarının ekolojik istekleri ve polifenoloksidaz enziminin kinetik özellikleri belirlenmiştir. O. onites ve O. vulgare ssp. hirtum taksonlarının yetiştiği ... -
Bazı flavonoidlerin sığır karaciğer glutatyon S-transferaz enzimi üzerine etkilerinin araştırılması
Aksoy, Ayşe Selda (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2018)Antiviral, antibakteriyel, antiinflamatuar, vazodilatör, antioksidan ve antiradikal aktivitelerinden dolayı flavonoid tüketimi oldukça popüler hale gelmiştir. Ancak bu bileşiklerin yan etkilerinin önemli bir sorun olduğu ... -
Bazı ilaçların koyun Paraoksonaz-1 üzerindeki etkilerinin araştırılması
Yüksel, Hatice; Ergün, Adem; Arslan, Mikail; Arslan, Oktay (2023)Paraoksonaz-1 (PON1, EC 3.1.8.1) birçok metabolik süreçlerde önemli rollere sahip bir metaloenzimdir. Bu çalışmada Karacabey Merinos koyunundan hidrofobik etkileşim tekniği ile PON1 (mPON1) saflaştırılmıştır. Saf enzim ... -
Bazı yeni yan kollu mozoaza-crown eterlerin sentezi ve kompleksleşme karakterleri
Ayaz, Meltem Tuğçe (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2018)Tez çalışmamızda bazı yeni yan kollu monoaza- crown eterler sentezlenmiştir. Bunlar; 3-[(1,4,7-trioksa-10-azasikloldodekan-10-il)metil]-4-(tert-butil)fenol (MT-4); 3-[(1,4,7,10-tetraoksa-13-azasiklopentadekan-13-il)metil ... -
Bentonite-supported catalase
Alkan, Salih; Ceylan,Hasan; Arslan, Oktay (Serbian Chemical Soc, 2005)The properties of the clay bentonite as a support for enzyme immobilization were studied using the enzyme catalase. Such an immobilization does not result in enzyme inactivation and constitutes a valuable method for ... -
Broyler karaciğerinden saflaştırılan glutatyon S-transferaz enzimi üzerine bazı ağır metallerin etkisinin incelenmesi
Tak, Tuğba (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2018)Glutatyon S-transferaz (GST; EC 2.5.1.18) ksenobiyotik metabolizmasında önemli role sahip multifonksiyonel bir enzimdir. Bu nedenle GST enzim aktivitesinin azalması karaciğerin detoksifikasyon kabiliyetinin düşmesine sebep ... -
Carbonic anhydrase activators: Activation of the β-carbonic anhydrase Nce103 from the yeast Saccharomyces cerevisiae with amines and amino acids
Işık, Semra; Köçkar, Feray; Aydın, Meltem; Arslan, Oktay; Güler, Özen Özensoy; Innocenti, Alessio; Scozzafava, Andrea; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2009)The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase (CA, EC 4.2.1.1) designated as scCA, was investigated for its activation with amines and amino acids. scCA was poorly activated ... -
Carbonic anhydrase from Cyprinus carpio
Özensoy, Özen; Arslan, Oktay; Işık, Semra (Elsevier GMBH, 2003)Carbonic anhydrase (CA) is the basic enzyme in the breathing function and catalyses the reversible hydration of CO2 to HCO3- and H+.A method is introduced to purify the carbonic anhydrase from erythrocytes of the carp ... -
Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides
Özensoy, Özen; Arslan, Oktay; Işık, Semra; Arslan, Mikail; Scozzafava, Andrea; Supuran, Claudiu T. (Taylor & Francis Ltd, 2005)The purification of red blood cell carbonic anhydrase (CA, EC 4.2. 1. 1) from ostrich (scCA) blood is reported, as well as an inhibition study of this enzyme with a series of aromatic and heterocylic sulfonamides. The ... -
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions
Işık, Semra; Köçkar, Feray; Arslan, Oktay; Güler, Özen Özensoy; Innocenti, Alessio; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2008)The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase (CA, EC 4.2.1.1) designated as scCA, has been cloned, purified, characterized kinetically, and investigated for its inhibition ... -
Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides
Özensoy, Özen; Puccetti, Luca; Fasolis, Giuseppe; Arslan, Oktay; Scozzafava, Andrea; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2005)The inhibition of the two transmembrane, tumor-associated isozymes of carbonic anhydrase (CA, EC 4.2.1.1) of human origin, hCA IX and XII, with a library of aromatic and heteroaromatic sulfonamides has been investigated. ... -
Carbonic anhydrase inhibitors: Inhibition of the β-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates
Işık, Semra; Köçkar, Feray; Aydın, Meltem; Arslan, Oktay; Güler, Özen Özensoy; Innocenti, Alessio; Scozzafava, Andrea; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2009)The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase ( CA, EC 4.2.1.1) designated as scCA, has been cloned, purified, characterized kinetically and investigated for its inhibition ...
