Yazar "Akkemik, Ebru" için listeleme
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The determination of the carbonic anhydrases activators in vitro effect of mixed donor crown ethers
Akkemik, Ebru; Çicek, Baki; Camadan, Yasemin; Çalışır, Ümit; Onbaşıoğlu, Zekai (Wiley, 2018)Carbonic anhydrases (CAs) play an important function in various physiological and pathological processes. Therefore, many researchers work in this field in order to design and synthesize new drugs. Both inhibitors and ... -
Investigation of in vitro and in silico effects of some novel carbazole Schiff bases on human carbonic anhydrase isoforms I and II
Camadan, Yasemin; Çiçek, Baki; Adem, Şevki; Çalışır, Ümit; Akkemik, Ebru (Taylor & Francis Inc, 2021)Carbonic anhydrases (CAs, EC4.2.1.1) are metalloenzymes that catalyse reversible hydration reaction of carbon dioxide to bicarbonate and protons. In recent years, there has been a great interest in inhibitors/activators ... -
İnsan karbonik anhidraz I,II izoenzim aktiviteleri üzerine bazı tiyocrown eterlerin etkisi
Akkemik, Ebru; Çalışır, Ümit; Çiçek, Baki (2017)Metalo enzim sınıfının bir üyesi olan karbonik anhidrazlar karbondioksitin bikarbonata ve protona dönüşümünü katalizlerler. Bir çok izoenzime sahip olan karbonik anhidrazların inhibisyonu veya aktivasyonu fizyolojik açıdan ... -
Microwave assisted synthesis of benzo-azacrown ethers and in vitro inhibition studies on hCA I–II
Sapmaz, Aycan; Çalışır, Ümit; Akkemik, Ebru; Çiçek, Baki (Pleiades Publishing, 2023)In this study, macro-ringed benzo-aza-oxa-crown ethers were synthesized by a cyclization reaction between 2,2′-dithiodianiline and mono/di/tri/tetraethylene glycol dichloride/dibromide with Cs2CO3 as a catalyst under ... -
Synthesis, characterizations of aryl-substituted dithiodibenzothioate derivatives, and investigating their anti-Alzheimer's properties
Çalışır, Ümit; Camadan, Yasemin; Çiçek, Baki; Akkemik, Ebru; Eyüpoğlu, Volkan; Adem, Şevki (Taylor & Francis Inc, 2021)The main objective of the present study was to synthesize potential inhibitor/activators of AChE and hCA I-II enzymes, which are thought to be directly related to Alzheimer's disease. Dithiodibenzothioate compounds were ...
