Browsing by Author "Önder, Ferah Cömert"
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Antiproliferative activity of Humulus lupulus extracts on human hepatoma (Hep3B), colon (HT-29) cancer cells and proteases, tyrosinase, beta-lactamase enzyme inhibition studies
Önder, Ferah Cömert; Ay, Mehmet; Türkoğlu, Sümeyye Aydoğan; Koçkar, Feray Tura; Çelik, Ayhan (Taylor & Francis Ltd, 2016)The aims of this study were to examine the antiproliferation of Humulus lupulus extracts on human hepatoma carcinoma (Hep3B) and human colon carcinoma (HT-29) cell lines along with enzyme inhibitory effects of the crude ... -
Humidity effect on real-time response of tetranitro-oxacalix[4] arene-based surface plasmon resonance (SPR) acetone sensor at room temperature
Şen, Sibel; Önder, Ferah Cömert; Çapan, Rifat; Ay, Mehmet; Erdoğan, Cansu Özkaya (Elsevier GMBH, 2022)We report the effect of humidity on the acetone sensitivity of nano-sized thin films obtained by spin coating the oxacalix[4]arenes(1,3) molecules on suitable substrates in this work. The surface morphologies and volatile ... -
Prodrugs for nitroreductase based cancer therapy-1: metabolite profile, cell cytotoxicity and molecular modeling ınteractions of nitro benzamides with ssap-ntrb
Güngör, Tuğba; Yetiş, Gülden; Önder, Ferah Cömert; Tokay, Esra; Tok, Tugba Taşkın; Çelik, Ayhan; Ay, Mehmet; Köçkar, Feray (Bentham Science Publ Ltd, 2018)Background: Directed Enzyme Prodrug Therapy (DEPT) as an alternative method against conventional cancer treatments, in which the non-toxic prodrug is converted to highly cytotoxic derivative, has attracted an ample attentions ... -
Prodrugs for nitroreductase based cancer therapy-2: Novel amide/Ntr combinations targeting PC3 cancer cells
Güngör, Tuğba; Önder, Ferah Cömert; Tokay, Esra; Gülhan, Ünzile Güven; Hacıoğlu, Nelin; Tok, Tuğba Taşkın; Çelik, Ayhan; Köçkar, Feray; Ay, Mehmet (Elsevier France-Editions Scientifiques Medicales Elsevier, 2019)The use of nitroreductases (NTR) that catalyze the reduction of nitro compounds by using NAD(P)H in GDEPT (Gene-directed enzyme prodrug therapy) studies which minimize toxicity at healthy cells and increases concentration ... -
Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer
Tokay, Esra; Güngör, Tuğba; Hacıoğlu, Nelin; Önder, Ferah Cömert; Gülhan, Ünzile Güven; Tok, Tuğba Taşkın; Çelik, Ayhan; Ay, Mehmet; Köçkar, Feray (Elsevier France-Editions Scientifiques Medicales Elsevier, 2020)Prodrugs for targeted tumor therapies have been extensively studied in recent years due to not only maximising therapeutic effects on tumor cells but also reducing or eliminating serious side effects on healthy cells. This ... -
A room temperature acetone sensor based on synthesized tetranitro-oxacalix[4]arenes: Thin film fabrication and sensing properties
Şen, Sibel; Önder, Ferah Cömert; Çapan, Rifat; Ay, Mehmet (Elsevier Sci Sa, 2020)Tetranitro-oxacalix[4]arenes were prepared to determine their thin film fabrication and gas sensing applications. Firstly, tetranitro-oxacalix[4]arenes (1-3) were synthesized via nucleophilic aromatic sub-stitution reaction ... -
Synthesis and biological evaluation of 2,4,6-trinitroaniline derivatives as potent antitumor agents
Hacıoğlu, Nelin; Güngör, Tuğba; Tokay, Esra; Önder, Ferah Cömert; Ay, Mehmet; Köçkar, Feray (Springer Wien, 2020)Nitro group-containing compounds are well known as effective anticancer drugs. The aim of the study is to synthesize a series of trinitroaniline derivatives to determine their potential antitumor activities on diverse ...
