Yazar "Çıkrıkcı, Kübra" için listeleme
-
Afinite kromatografisi yöntemi ile saflaştırılan karbonik anhidraz (I-II) izoenzimleri üzerine bazı pestisitlerin in vitro etkilerinin araştırılması
Gençer, Nahit; Baltacı, Aybike; Çıkrıkcı, Kübra (Doç. Dr. Fikret TÜRKAN, 2024)Bu çalışmanın amacı; çevre ve insan sağlığı için toksisitesi yüksek olan bazı pestisitlerin hidrataz aktivite yöntemi kullanılarak karbonik anhidraz izoenzimleri (hCA I ve II) üzerine etkilerini araştırmaktır. İnsan kan ... -
Effect of 3-amino-1,2,4-triazole-5-carboxylic acid on human blood erythrocyte catalase
Çıkrıkcı, Kübra; Gençer, Nahit (Barbaros Akkurt, 2024)Catalase is an antioxidant enzyme with great therapeutic potential that scavenges hydrogen peroxide, a reactive oxygen species produced during cellular metabolism. Substances containing 1,2,4- triazole structures are ... -
The effect of total anthocyanins extracted from sweet cherry cultivars on carbonic anhydrases and antioxidant activity
Sönmez, Fatih; Güneşli, Zuhal; Demir, Taki; Çıkrıkcı, Kübra; Ergün, Adem; Gencer, Nahit; Arslan, Oktay (Springer, 2022)Total anthocyanins were extracted from eleven sweet cherry cultivars grown in Sakarya, Turkey. In vitro inhibition effects of extracted total anthocyanins on purified carbonic anhydrase I and II were investigated by using ... -
In vitro activation of paraoxonase 1 by steroids: An experimental, molecular docking, and molecular modelling study
Deveci, Ufuk; Çıkrıkcı, Kübra; Kuru, Ali; Yıldırım, Kudret; Tilahun, Muhammed Muhammed; Gencer, Nahit (John Wiley and Sons Inc, 2024)Paraoxonase 1 (PON1) is an antioxidant enzyme that prevents lipid oxidation by hydrolysing lipid peroxides in the oxidised low-density lipoprotein (LDL) structure, bound to high-density lipoprotein (HDL) in serum, and ... -
In vitro effects of thirty-eight cardiac drugs on human serum paraoxonase
Argan, Onur; Çıkrıkcı, Kübra; Uslu, Harun; Gencer, Nahit (Wiley, 2022)In this study, the effects of 38 commonly used cardiac drugs on the human paraoxonase (PON1) were investigated. PON1 was purified from human serum blood by ammonium sulfate precipitation (60%-80%) and hydrophobic interaction ... -
Microwave-assisted synthesis of 1-substituted-1H-benzimidazolium salts: Non-competitive inhibition of human carbonic anhydrase I and II
Karlık, Özgül; Gencer, Nahit; Karataş, Mert O.; Ergun, Adem; Çıkrıkcı, Kübra; Arslan, Oktay; Alıcı, Bülent; Cıkla, Işın Kılıç; Özdemir, Namık (Wiley-V C H Verlag GMBH, 2019)A series of 1-substituted-1H-benzimidazolium p-toluenesulfonate salts were synthesized in good yields by the reaction of 1-substituted benzimidazole derivatives and p-toluenesulfonic acid under microwave irradiation. Two ... -
Obstrüktif apne sendromu olan bireylerde paraoksonaz (PON1) aktivitesi ve pon1 fenotipinin belirlenmesi
Çıkrıkcı, Kübra (Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, 2018)PON1, karaciğer tarafından sentezlenen, kalsiyum içeren bir serum esterazdır. Serumda, yüksek yoğunluklu liporoteinlerle (HDL) yakından ilişkilidir. PON1, böcek öldürücü ve sinir gazı olarak yaygın kullanılan organofosfat ... -
Synthesis and investigation of carbonic anhydrase I and II activity of dihydrobenzo[h]quinazolin-2-yl thiourea compounds
Taşcı, Merve; Arslan, Mustafa; Çıkrıkcı, Kübra; Ergün, Adem; Gençer, Nahit; Arslan, Oktay (Springer, 2023)Thirteen novel compounds in a series of dihydrobenzo[h]quinazolin-2-yl thiourea compounds (7a–m) were synthesized and characterized using FT-IR, 1H, 13C NMR spectroscopy, and elemental analysis. Some inhibition parameters ... -
Synthesis of carbazole bearing pyridopyrimidine-substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity
Rifati-Nixha, Arleta; Arslan, Mustafa; Gencer, Nahit; Çıkrıkcı, Kübra; Gökçe, Başak (Wiley, 2019)The synthesis of carbazole containing pyridopyrimidine-substituted sulfonamide derivatives (3a-i) and their inhibitory effects on human carbonic anhydrase (hCA) I and II were studied. Spectral data and elemental analysis ... -
Synthesis, enzyme inhibition, and molecular docking studies of a novel chalcone series bearing benzothiazole scaffold
Musatat, Ahmad Badreddin; Atahan, Alparslan; Ergün, Adem; Çıkrıkcı, Kübra; Gençer, Nahit; Arslan, Oktay; Zengin, Mustafa (Wiley, 2023)This study reports the facile synthesis of a novel series of benzothiazole-chalcones, in addition to their inhibitory profile on important metabolic enzymes including human carbonic anhydrases (hCA-I, hCA-II) and paraoxonase ... -
Synthesis, in vitro inhibition effect of novel phthalocyanine complexes as carbonic anhydrase and paraoxonase enzyme inhibitors
Güzel, Emre; Arslan, Barış Seçkin; Çıkrıkcı, Kübra; Ergun, Adem; Gencer, Nahit; Arslan, Oktay; Şişman, İlkay; Nebioğlu, Mehmet (World Sci Publ Co Inc, 2020)The preparation and assessment of carbonic anhydrase and paraoxonase enzyme inhibition properties of 3-(2-(5-amino-4-(4-bromophenyl)-3-methyl-1H-pyrazol-1-yl)ethoxy)phthalonitrile (2) and its nitrogen-containing non-peripheral ...
